HCID 11154545, compound → 4-Isopropoxy-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

HRID 2267730Notes

Reaction equation

HRID 2267730 reaction equation
[N:1]1([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17]([C:19]3[NH:20][C:21]4[C:26]([CH:27]=3)=[C:25]([O:28][CH:29]([CH3:31])[CH3:30])[CH:24]=[CH:23][CH:22]=4)=[O:18])[CH2:12][CH2:11]2)[CH2:7][CH2:6][CH2:5]C[CH2:3][CH2:2]1.Cl.Cl.Cl.NC1CCN(CCN2CCC([OH:50])CC2)CC1>>[OH:50][CH:5]1[CH2:3][CH2:2][N:1]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17]([C:19]3[NH:20][C:21]4[C:26]([CH:27]=3)=[C:25]([O:28][CH:29]([CH3:30])[CH3:31])[CH:24]=[CH:23][CH:22]=4)=[O:18])[CH2:12][CH2:11]2)[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 11154545HCID 11154545, compoundHCID 66841786HCID 66841786, compound

Product 1

HCID 113393834-Isopropoxy-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to Example 1 from 4-isopropoxy-1H-indole-2-carboxylic acid 74 (preparation see Example 2) and amine 21.

Sources & evidence

ORD record
ord-433e8f9ac3484c0793377c48ebfb8459
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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