1-(2-(Azepan-1-yl)ethyl)piperidin-4-amine trihydrochloride → 4-Isobutoxy-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

HRID 2267736Notes

Reaction equation

HRID 2267736 reaction equation
[CH2:1]([O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[CH:8]=[C:9]([C:15]([OH:17])=O)[NH:10]2)[CH:2]([CH3:4])[CH3:3].Cl.Cl.Cl.[N:21]1([CH2:28][CH2:29][N:30]2[CH2:35][CH2:34][CH:33]([NH2:36])[CH2:32][CH2:31]2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[N:21]1([CH2:28][CH2:29][N:30]2[CH2:31][CH2:32][CH:33]([NH:36][C:15]([C:9]3[NH:10][C:11]4[C:7]([CH:8]=3)=[C:6]([O:5][CH2:1][CH:2]([CH3:3])[CH3:4])[CH:14]=[CH:13][CH:12]=4)=[O:17])[CH2:34][CH2:35]2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 668413931-(2-(Azepan-1-yl)ethyl)piperidin-4-amine trihydrochlorideHCID 668416074-Isobutoxy-1H-indole-2-carboxylic acid

Product 1

HCID 114420474-Isobutoxy-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

Procedure

This compound is synthesized analogously to Example 1 from 4-Isobutoxy-1H-indole-2-carboxylic acid 80 (preparation see below) and amine 5.

Sources & evidence

ORD record
ord-d87f942fd2184201810c627accc4138f
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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