HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-(phenylmethoxy)-1H-indole-2-carboxylate → Ethyl 4-hydroxy-1H-indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-(phenylmethoxy)-1H-indole-2-carboxylate | HCID 119707 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 4-hydroxy-1H-indole-2-carboxylate | HCID 13274763 | — |
Reaction Steps
To a solution of 4-Benzyloxy-1H-indole-2-carboxylic acid ethyl ester (29 g, 98.2 mmol) in a mixture of MeOH (750 ml) and DCM (500 ml) is added 1 gram of Pd/C (10%). It is hydrogenated under normal pressure for 24 hours. After filtration and evaporation a white powder is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-0dc1deef060549b18fe85bad03ab2606 |
| Source note | uspto-grants-2010_12 |