4-Isobutoxy-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide → 4-isobutoxy-1H-indole-2-carboxylic acid {1-[2-(2,6-dimethyl-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

HRID 2267742Notes

Reaction equation

HRID 2267742 reaction equation
[N:1]1([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17]([C:19]3[NH:20][C:21]4[C:26]([CH:27]=3)=[C:25]([O:28][CH2:29][CH:30]([CH3:32])[CH3:31])[CH:24]=[CH:23][CH:22]=4)=[O:18])[CH2:12][CH2:11]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.Cl.Cl.[CH3:36][C@H]1CCC[C@@H](C)N1CCN1CCC(N)CC1>>[CH3:36][CH:7]1[CH2:6][CH2:5][CH2:4][CH:3]([CH3:2])[N:1]1[CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][CH:13]([NH:16][C:17]([C:19]2[NH:20][C:21]3[C:26]([CH:27]=2)=[C:25]([O:28][CH2:29][CH:30]([CH3:31])[CH3:32])[CH:24]=[CH:23][CH:22]=3)=[O:18])[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 114420474-Isobutoxy-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amideHCID 668414041-[2-((2S,6R)-2,6-Dimethyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine trihydrochloride

Product 1

HCID 668415784-isobutoxy-1H-indole-2-carboxylic acid {1-[2-(2,6-dimethyl-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to Example 1 from 4-Isobutoxy-1H-indole-2-carboxylic acid 80 (preparation see Example 8) and amine 27.

Sources & evidence

ORD record
ord-a10dd3966659442dae75a811b0be8eed
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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