4-Isobutoxy-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide → 4-Isobutoxy-1H-indole-2-carboxylic acid {1-[2-(3-hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-ethyl]-piperidin-4-yl}-amide

HRID 2267744Notes

Reaction equation

HRID 2267744 reaction equation
N1(CCN2CCC(N[C:17]([C:19]3[NH:20][C:21]4[C:26]([CH:27]=3)=[C:25]([O:28][CH2:29][CH:30]([CH3:32])[CH3:31])[CH:24]=[CH:23][CH:22]=4)=[O:18])CC2)CCCCCC1.Cl.Cl.Cl.[NH2:36][CH:37]1[CH2:42][CH2:41][N:40]([CH2:43][CH2:44][N:45]2[CH:50]3[CH2:51][CH2:52][CH:46]2[CH2:47][CH:48]([OH:53])[CH2:49]3)[CH2:39][CH2:38]1>>[OH:53][CH:48]1[CH2:49][CH:50]2[N:45]([CH2:44][CH2:43][N:40]3[CH2:41][CH2:42][CH:37]([NH:36][C:17]([C:19]4[NH:20][C:21]5[C:26]([CH:27]=4)=[C:25]([O:28][CH2:29][CH:30]([CH3:32])[CH3:31])[CH:24]=[CH:23][CH:22]=5)=[O:18])[CH2:38][CH2:39]3)[CH:46]([CH2:52][CH2:51]2)[CH2:47]1

Participants

3

Reactant 2

HCID 114420474-Isobutoxy-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amideHCID 668415748-[2-(4-Amino-piperidin-1-yl)-ethyl]-8-aza-bicyclo[3.2.1]octan-3-ol trihydrochloride

Product 1

HCID 113173264-Isobutoxy-1H-indole-2-carboxylic acid {1-[2-(3-hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-ethyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to Example 1 from 4-Isobutoxy-1H-indole-2-carboxylic acid 80 (preparation see Example 8) and amine 24.

Sources & evidence

ORD record
ord-74cef819ac4e451c84c12b6fedf96b20
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

Loading…