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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2267755Generated: October 31, 2026

4-Cyclobutylmethoxy-1H-indole-2-carboxylic acid → 4-Cyclobutylmethoxy-1H-indole-2-carboxylic acid {1-[(S)-2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

https://huagongshe.com/reaction/2267755

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Cyclobutylmethoxy-1H-indole-2-carboxylic acidHCID 59152682—
Reactant(3S,4S)-1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-3-methyl-piperidin-4-ol tri-hydrochlorideHCID 66841745—
Product4-Cyclobutylmethoxy-1H-indole-2-carboxylic acid {1-[(S)-2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-propyl]-piperidin-4-yl}-amideHCID 59600208—

Reaction Steps

This compound is synthesized analogously to example 1 from 4-cyclobutylmethoxy-1H-indole-2-carboxylic acid, 82 (see example 22) and amine 56.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07858781B2
Source datasetuspto-grants-2010_12
ORD IDord-03f4b05d444e45b5816834964fbdfd3d
Source noteuspto-grants-2010_12