1-(2-(Azepan-1-yl)ethyl)piperidin-4-amine trihydrochloride → 4-(1,2-Dimethyl-propoxy)-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

HRID 2267759Notes

Reaction equation

HRID 2267759 reaction equation
[CH3:1][CH:2]([O:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[C:10]([C:16]([OH:18])=O)[NH:11]2)[CH:3]([CH3:5])[CH3:4].Cl.Cl.Cl.[N:22]1([CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][CH:34]([NH2:37])[CH2:33][CH2:32]2)[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[N:22]1([CH2:29][CH2:30][N:31]2[CH2:32][CH2:33][CH:34]([NH:37][C:16]([C:10]3[NH:11][C:12]4[C:8]([CH:9]=3)=[C:7]([O:6][CH:2]([CH3:1])[CH:3]([CH3:4])[CH3:5])[CH:15]=[CH:14][CH:13]=4)=[O:18])[CH2:35][CH2:36]2)[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 668413931-(2-(Azepan-1-yl)ethyl)piperidin-4-amine trihydrochlorideHCID 668415954-(1,2-Dimethyl-propoxy)-1H-indole-2-carboxylic acid

Product 1

HCID 114084224-(1,2-Dimethyl-propoxy)-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

Procedure

This compound is synthesized analogously to Example 1 from 4-(1,2-Dimethyl-propoxy)-1H-indole-2-carboxylic acid 88 (preparation see below) and amine 5.

Sources & evidence

ORD record
ord-59915111a97b498c97f758c94974df98
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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