HCID 66841786, compound → 4-(4-Methyl-pentyloxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochloride

HRID 2267765Notes

Reaction equation

HRID 2267765 reaction equation
[CH3:1][CH:2]([CH3:19])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[C:10]([C:16]([OH:18])=O)[NH:11]2.[ClH:20].Cl.Cl.[NH2:23][CH:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][N:32]2[CH2:37][CH2:36][CH:35]([OH:38])[CH2:34][CH2:33]2)[CH2:26][CH2:25]1>>[ClH:20].[ClH:20].[OH:38][CH:35]1[CH2:34][CH2:33][N:32]([CH2:31][CH2:30][N:27]2[CH2:26][CH2:25][CH:24]([NH:23][C:16]([C:10]3[NH:11][C:12]4[C:8]([CH:9]=3)=[C:7]([O:6][CH2:5][CH2:4][CH2:3][CH:2]([CH3:1])[CH3:19])[CH:15]=[CH:14][CH:13]=4)=[O:18])[CH2:29][CH2:28]2)[CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 66841786HCID 66841786, compoundHCID 668420304-(4-methyl-pentyloxy)-1H-indole-2-carboxylic acid

Product 1

HCID 668415884-(4-Methyl-pentyloxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochloride

Procedure

This compound is synthesized analogously to Example 1 from 4-(4-methyl-pentyloxy)-1H-indole-2-carboxylic acid (91) (preparation see below) and amine 21.

Sources & evidence

ORD record
ord-49727b509bdb4dbebae14c68655b67d5
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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