4-(Furan-3-ylmethoxy)-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide → 4-(Furan-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

Participants

Role	Name	HCID	Charge
Reactant	4-(Furan-3-ylmethoxy)-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide	HCID 11488109	—
Reactant	(3S,4S)-1-[2-(4-Amino-piperidin-1-yl)-ethyl]-3-methyl-piperidin-4-ol trihydrochloride	HCID 66841748	—
Product	4-(Furan-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide	HCID 11236981	—

Reaction Steps

This compound is synthesized analogously to example 1 from 4-(furan-3-ylmethoxy)-1H-indole-2-carboxylic acid 95 (preparation see example 36) and amine 14.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07858781B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-ded9ea50625a4955ba5467a219296b76
Source note	uspto-grants-2010_12