4-(benzyloxy)-1H-indole-2-carboxylic acid → 4-Benzyloxy-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

HRID 2267779Notes

Reaction equation

HRID 2267779 reaction equation
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:18]([OH:20])=O)[NH:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.Cl.Cl.[N:24]1([CH2:31][CH2:32][N:33]2[CH2:38][CH2:37][CH:36]([NH2:39])[CH2:35][CH2:34]2)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[N:24]1([CH2:31][CH2:32][N:33]2[CH2:34][CH2:35][CH:36]([NH:39][C:18]([C:12]3[NH:13][C:14]4[C:10]([CH:11]=3)=[C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:17]=[CH:16][CH:15]=4)=[O:20])[CH2:37][CH2:38]2)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 27354974-(benzyloxy)-1H-indole-2-carboxylic acidHCID 668413931-(2-(Azepan-1-yl)ethyl)piperidin-4-amine trihydrochloride

Product 1

HCID 113519794-Benzyloxy-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

Procedure

This compound is synthesized analogously to Example 1 from 4-Benzyloxy-1H-indole-2-carboxylic acid and amine 5.

Sources & evidence

ORD record
ord-590d1591f86a4d4a8d67c16d0b790608
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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