反应详情

温度

85 °C

101 (7.7 g, 16.3 mmol) is dissolved in 15 ml of a 1:1:1 mixture of THF/water/ethanol and after addition of KOH pellets (5.4 g, 81.9 mmol) the mixture is stirred for 2 h at 85° C. Then the organic phase is evaporated under reduced pressure. The residue is dissolved in ethyl acetate, acidified with 2M HCl and filtered off. The crude product is purified by crystallisation from ethyl acetate.

1. customThen the organic phase is evaporated under reduced pressure
2. dissolutionThe residue is dissolved in ethyl acetate
3. filtrationfiltered off
4. customThe crude product is purified by crystallisation from ethyl acetate