4-(benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid → 4-(Benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-piperidin-4-yl}-amide dihydrochloride

HRID 2267795Notes

Reaction equation

HRID 2267795 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][O:11][C:12]2[CH:20]=[CH:19][CH:18]=[C:17]3[C:13]=2[CH:14]=[C:15]([C:21](O)=[O:22])[NH:16]3)=[CH:2]1.[ClH:24].Cl.Cl.[C@H:27]1([CH2:37][N:38]2[CH2:43][CH2:42][CH:41]([NH2:44])[CH2:40][CH2:39]2)[C@@H:36]2[N:31]([CH2:32][CH2:33][CH2:34][CH2:35]2)[CH2:30][CH2:29][CH2:28]1>>[ClH:24].[ClH:24].[C@H:27]1([CH2:37][N:38]2[CH2:43][CH2:42][CH:41]([NH:44][C:21]([C:15]3[NH:16][C:17]4[C:13]([CH:14]=3)=[C:12]([O:11][CH2:10][C:3]3[C:4]5[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=5[O:1][CH:2]=3)[CH:20]=[CH:19][CH:18]=4)=[O:22])[CH2:40][CH2:39]2)[C@@H:36]2[N:31]([CH2:32][CH2:33][CH2:34][CH2:35]2)[CH2:30][CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 596001304-(benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acidHCID 66841583HCID 66841583, compound

Product 1

HCID 668414964-(Benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-piperidin-4-yl}-amide dihydrochloride

Procedure

This compound is synthesized from 4-(benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid (105) (preparation see below) and amine 61 analogously to the method described in example 1.

Sources & evidence

ORD record
ord-75ad832b12a440a0913629f82864e20b
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

Loading…