4-(benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid → 4-(Benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(S)-2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

HRID 2267799Notes

Reaction equation

HRID 2267799 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][O:11][C:12]2[CH:20]=[CH:19][CH:18]=[C:17]3[C:13]=2[CH:14]=[C:15]([C:21](O)=[O:22])[NH:16]3)=[CH:2]1.Cl.Cl.Cl.[NH2:27][CH:28]1[CH2:33][CH2:32][N:31]([CH2:34][C@@H:35]([N:37]2[CH2:42][CH2:41][C@H:40]([OH:43])[C@@H:39]([CH3:44])[CH2:38]2)[CH3:36])[CH2:30][CH2:29]1>>[OH:43][C@H:40]1[CH2:41][CH2:42][N:37]([C@@H:35]([CH3:36])[CH2:34][N:31]2[CH2:32][CH2:33][CH:28]([NH:27][C:21]([C:15]3[NH:16][C:17]4[C:13]([CH:14]=3)=[C:12]([O:11][CH2:10][C:3]3[C:4]5[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=5[O:1][CH:2]=3)[CH:20]=[CH:19][CH:18]=4)=[O:22])[CH2:29][CH2:30]2)[CH2:38][C@@H:39]1[CH3:44]

Participants

3

Reactant 2

HCID 596001304-(benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acidHCID 66841745(3S,4S)-1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-3-methyl-piperidin-4-ol tri-hydrochloride

Product 1

HCID 112841924-(Benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(S)-2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-(benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid, 105 (see example 50) and amine 56.

Sources & evidence

ORD record
ord-a7b3abd11d144df8930ab733a71b566b
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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