4-(5-fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid → 4-(5-Fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(S)-2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

HRID 2267815Notes

Reaction equation

HRID 2267815 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[C:7]([CH2:10][O:11][C:12]3[CH:20]=[CH:19][CH:18]=[C:17]4[C:13]=3[CH:14]=[C:15]([C:21](O)=[O:22])[NH:16]4)[C:6]=2[CH:24]=1.Cl.Cl.Cl.[NH2:28][CH:29]1[CH2:34][CH2:33][N:32]([CH2:35][C@@H:36]([N:38]2[CH2:43][CH2:42][C@H:41]([OH:44])[C@@H:40]([CH3:45])[CH2:39]2)[CH3:37])[CH2:31][CH2:30]1>>[OH:44][C@H:41]1[CH2:42][CH2:43][N:38]([C@@H:36]([CH3:37])[CH2:35][N:32]2[CH2:31][CH2:30][CH:29]([NH:28][C:21]([C:15]3[NH:16][C:17]4[C:13]([CH:14]=3)=[C:12]([O:11][CH2:10][C:7]3[C:6]5[CH:24]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=5[O:9][CH:8]=3)[CH:20]=[CH:19][CH:18]=4)=[O:22])[CH2:34][CH2:33]2)[CH2:39][C@@H:40]1[CH3:45]

Participants

3

Reactant 2

HCID 668414244-(5-fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acidHCID 66841745(3S,4S)-1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-3-methyl-piperidin-4-ol tri-hydrochloride

Product 1

HCID 117863274-(5-Fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(S)-2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-(5-fluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid, 113 (see example 60) and amine 56.

Sources & evidence

ORD record
ord-2aaea9d3234442b68fbaa08c20dbd432
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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