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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2267817Generated: November 2, 2026

4-(4,6-difluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid → 4-(4,6-Difluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-piperidin-4-yl}-amide dihydrochloride

https://huagongshe.com/reaction/2267817

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(4,6-difluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acidHCID 66841421—
ReactantHCID 66841583HCID 66841583—
Product4-(4,6-Difluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-piperidin-4-yl}-amide dihydrochlorideHCID 66841461—

Reaction Steps

This compound is synthesized from 4-(4,6-difluoro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid (115) (preparation see below) and amine 61 analogously to the method described in example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07858781B2
Source datasetuspto-grants-2010_12
ORD IDord-c0430f68d1c34b8e8b8044c43082913a
Source noteuspto-grants-2010_12