4-(7-chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid → 4-(7-Chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-piperidin-4-yl}-amide dihydrochloride

HRID 2267822Notes

Reaction equation

HRID 2267822 reaction equation
[Cl:1][C:2]1[C:10]2[O:9][CH:8]=[C:7]([CH2:11][O:12][C:13]3[CH:21]=[CH:20][CH:19]=[C:18]4[C:14]=3[CH:15]=[C:16]([C:22]([OH:24])=O)[NH:17]4)[C:6]=2[CH:5]=[CH:4][CH:3]=1.[ClH:25].Cl.Cl.[C@H:28]1([CH2:38][N:39]2[CH2:44][CH2:43][CH:42]([NH2:45])[CH2:41][CH2:40]2)[C@@H:37]2[N:32]([CH2:33][CH2:34][CH2:35][CH2:36]2)[CH2:31][CH2:30][CH2:29]1>>[ClH:1].[ClH:25].[C@H:28]1([CH2:38][N:39]2[CH2:44][CH2:43][CH:42]([NH:45][C:22]([C:16]3[NH:17][C:18]4[C:14]([CH:15]=3)=[C:13]([O:12][CH2:11][C:7]3[C:6]5[CH:5]=[CH:4][CH:3]=[C:2]([Cl:1])[C:10]=5[O:9][CH:8]=3)[CH:21]=[CH:20][CH:19]=4)=[O:24])[CH2:41][CH2:40]2)[C@@H:37]2[N:32]([CH2:33][CH2:34][CH2:35][CH2:36]2)[CH2:31][CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 668414324-(7-chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acidHCID 66841583HCID 66841583, compound

Product 1

HCID 668419444-(7-Chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-piperidin-4-yl}-amide dihydrochloride

Procedure

This compound is synthesized from 4-(7-chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid (116) (preparation see below) and amine 61 analogously to the method described in example 1.

Sources & evidence

ORD record
ord-7b5bdb8f390a4cee81ba5dc976408347
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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