1-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-piperidin-4-ylamine → HCID 59600177, compound

HRID 2267843Notes

Reaction equation

HRID 2267843 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[C:9]([CH2:12][O:13][C:14]3[CH:22]=[CH:21][CH:20]=[C:19]4[C:15]=3[CH:16]=[C:17]([C:23]([OH:25])=O)[NH:18]4)=[CH:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.[C@H:26]1([CH2:36][N:37]2[CH2:42][CH2:41][CH:40]([NH2:43])[CH2:39][CH2:38]2)[C@@H:35]2[N:30]([CH2:31][CH2:32][CH2:33][CH2:34]2)[CH2:29][CH2:28][CH2:27]1>>[C@H:26]1([CH2:36][N:37]2[CH2:42][CH2:41][CH:40]([NH:43][C:23]([C:17]3[NH:18][C:19]4[C:15]([CH:16]=3)=[C:14]([O:13][CH2:12][C:9]3[C:8]5[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][C:7]=5[O:11][CH:10]=3)[CH:22]=[CH:21][CH:20]=4)=[O:25])[CH2:39][CH2:38]2)[C@@H:35]2[N:30]([CH2:31][CH2:32][CH2:33][CH2:34]2)[CH2:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 596001891-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-piperidin-4-ylamineHCID 668413694-(4-methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid

Product 1

HCID 59600177HCID 59600177, compound

Procedure

This compound is synthesized analogously to example 1 from 4-(4-methoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid (122) (preparation see below) and 1-[(1S,9aR)-1-(octahydro-quinolizin-1-yl)methyl]-piperidin-4-ylamine, 61.

Sources & evidence

ORD record
ord-c8a32a09ad8f4e3792b5dd61d33fc93a
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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