HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-(2-Amino-4-methyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 4-(3,5-Difluoro-2-nitro-phenoxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 66842102 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 4-(2-Amino-4-methyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 66842048 | — |
Reaction Steps
138 (570 mg, 1.675 mmol) is dissolved in 150 ml of ethanol and, after addition of Pd—C (200 mg), the mixture is hydrogenated at room temperature for 2 hours. The mixture is filtrated over celite to remove the catalyst and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-539f01085a0d4fa5b0ea1a81c3238929 |
| Source note | uspto-grants-2010_12 |