HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 66841616, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 4-(3-Fluoro-phenoxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 66841292 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 66841616 | HCID 66841616 | — |
Reaction Steps
144 (440 mg, 1.47 mmol) is dissolved in 10 ml of methanol and treated with a solution of LiOH (70 mg, 1.47 mmol) in 5 ml of water. The mixture is stirred at room temperature for 18 hours. After evaporation, the crude product is acidified at 0° C. with 2M HCl and extracted with ethyl acetate. The organic layers are dried over sodium sulphate and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-99631d1341364892a8a7dbff32b61ca3 |
| Source note | uspto-grants-2010_12 |