1-(2-(Azepan-1-yl)ethyl)piperidin-4-amine trihydrochloride → 4-(3,5-Difluoro-phenoxy)-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

HRID 2267891Notes

Reaction equation

HRID 2267891 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:18]=[C:19]([F:21])[CH:20]=1)[O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[CH:8]=[C:9]([C:15]([OH:17])=O)[NH:10]2.Cl.Cl.Cl.[N:25]1([CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][CH:37]([NH2:40])[CH2:36][CH2:35]2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[N:25]1([CH2:32][CH2:33][N:34]2[CH2:35][CH2:36][CH:37]([NH:40][C:15]([C:9]3[NH:10][C:11]4[C:7]([CH:8]=3)=[C:6]([O:5][C:4]3[CH:18]=[C:19]([F:21])[CH:20]=[C:2]([F:1])[CH:3]=3)[CH:14]=[CH:13][CH:12]=4)=[O:17])[CH2:38][CH2:39]2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 668413931-(2-(Azepan-1-yl)ethyl)piperidin-4-amine trihydrochlorideHCID 668416404-(3,5-difluoro-phenoxy)-1H-indole-2-carboxylic acid

Product 1

HCID 596002344-(3,5-Difluoro-phenoxy)-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

Procedure

This compound is synthesized analogously to Example 1 from 4-(3,5-difluoro-phenoxy)-1H-indole-2-carboxylic acid 153 (preparation see below) and amine 5.

Sources & evidence

ORD record
ord-9db4611b3a4f416ca126b47220b3190b
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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