HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(6-Chloro-pyridin-2-yloxy)-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(6-Chloro-pyridin-2-yloxy)-1H-indole-2-carboxylic acid ethyl ester | HCID 86066032 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(6-Chloro-pyridin-2-yloxy)-1H-indole-2-carboxylic acid | HCID 86649944 | — |
Reaction Steps
160 (100 mg, 0.315 mmol) is dissolved in 4 ml of methanol and treated with a solution of NaOH (1 ml, 2N). The mixture is stirred 1 hour at room temperature. The reaction mixture is acidified with HCl (1 ml, 2N) and evaporated. The crude mixture is used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-3d84d68976704343b1b2c1b241cf2a67 |
| Source note | uspto-grants-2010_12 |