HCID 66841456, compound → HCID 59600255, compound

HRID 2267907Notes

Reaction equation

HRID 2267907 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]2[NH:11][C:12]3[C:17]([CH:18]=2)=[C:16]([O:19][CH2:20][C:21]2[CH:25]=[CH:24][O:23][CH:22]=2)[CH:15]=[CH:14][CH:13]=3)=[O:9])[CH2:3][CH2:2]1.O[C@H:27](C)[CH2:28][N:29]1[CH2:34][CH2:33][C@@H:32]([O:35]C(=O)C(C)(C)C)[C@H:31]([CH3:42])[CH2:30]1.[C:44](OC(=O)NC1CCN(C[C@@H](N2CCC(O)CC2)C)CC1)(C)(C)C>>[OH:35][C@@H:32]1[CH2:33][CH2:34][N:29]([C@@H:28]([CH3:27])[CH2:44][N:1]2[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]3[NH:11][C:12]4[C:17]([CH:18]=3)=[C:16]([O:19][CH2:20][C:21]3[CH:25]=[CH:24][O:23][CH:22]=3)[CH:15]=[CH:14][CH:13]=4)=[O:9])[CH2:3][CH2:2]2)[CH2:30][C@H:31]1[CH3:42]

Participants

4

Reactant 3

HCID 66841456HCID 66841456, compoundHCID 66841576HCID 66841576, compoundHCID 66841883HCID 66841883, compound

Product 1

HCID 59600255HCID 59600255, compound

Procedure

This compound is synthesized from 4-(furan-3-ylmethoxy)-1H-indole-2-carboxylic acid piperidin-4-ylamide, 165 (see example 133) and 2,2-dimethyl-propionic acid (3R,4R)-1-((R)-2-hydroxy-propyl)-3-methyl-piperidin-4-yl ester, 164 (preparation see example 130) analogously to the method described in example 127, followed by pivaloyl cleavage as described for amine 55.

Sources & evidence

ORD record
ord-5ee8da53cbe342c181895b652fe3836a
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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