(-)-LUPININE → HCID 72335856, compound

HRID 2267908Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]2[NH:11][C:12]3[C:17]([CH:18]=2)=[C:16]([O:19][CH2:20][C:21]2[N:22]=[C:23]([CH3:26])[S:24][CH:25]=2)[CH:15]=[CH:14][CH:13]=3)=[O:9])[CH2:3][CH2:2]1.[C@H:27]1([CH2:37]O)[C@@H:36]2[N:31]([CH2:32][CH2:33][CH2:34][CH2:35]2)[CH2:30][CH2:29][CH2:28]1>>[CH:27]1([CH2:37][N:1]2[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]3[NH:11][C:12]4[C:17]([CH:18]=3)=[C:16]([O:19][CH2:20][C:21]3[N:22]=[C:23]([CH3:26])[S:24][CH:25]=3)[CH:15]=[CH:14][CH:13]=4)=[O:9])[CH2:3][CH2:2]2)[CH:36]2[N:31]([CH2:32][CH2:33][CH2:34][CH2:35]2)[CH2:30][CH2:29][CH2:28]1

Participants

Reactant 2

HCID 91461(-)-LUPININE

HCID 66841618HCID 66841618, compound

Product 1

HCID 72335856HCID 72335856, compound

Procedure

This compound is synthesized from 4-(2-methyl-thiazol-4-ylmethoxy)-1H-indole-2-carboxylic acid piperidin-4-ylamide, (167, preparation see below) and (1R,9aR)-1-(octahydro-quinolizin-1-yl)-methanol analogously to the method described in example 127.

Sources & evidence

ORD record: ord-38b987360ff84f7db9c9764e8c8df944
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07858781B2

Reaction notes

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