HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(4-Methoxy-phenyl)-1H-indole-2-carboxylic acid piperidin-4-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(4-Methoxy-phenyl)-1H-indole-2-carboxylic acid (1-benzyl-piperidin-4-yl)-amide | HCID 66841881 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(4-Methoxy-phenyl)-1H-indole-2-carboxylic acid piperidin-4-ylamide | HCID 66841797 | — |
Reaction Steps
179 (4 g, 9.1 mmol) is dissolved in 100 ml of methanol, flushed with argon and, after addition of Pd—C (100 mg) and 2M HCl (5.5 ml, 11 mmol), the mixture is hydrogenated at room temperature for 3 h. The mixture is filtrated over celite and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-b52cbfdb8adc43358b98cfea047e3c33 |
| Source note | uspto-grants-2010_12 |