4-Ethoxyphenylboronic acid → 4-(4-Ethoxy-phenyl)-1h-indole-2-carboxylic acid piperidin-4-ylamide

HRID 2267918Notes

Reaction equation

HRID 2267918 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7](B(O)O)=[CH:6][CH:5]=1)[CH3:2].[NH:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]2[NH:23][C:24]3[C:29]([CH:30]=2)=[C:28](C2C=CC(OC)=CC=2)[CH:27]=[CH:26][CH:25]=3)=[O:21])[CH2:15][CH2:14]1>>[NH:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]2[NH:23][C:24]3[C:29]([CH:30]=2)=[C:28]([C:7]2[CH:8]=[CH:9][C:4]([O:3][CH2:1][CH3:2])=[CH:5][CH:6]=2)[CH:27]=[CH:26][CH:25]=3)=[O:21])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 27343514-Ethoxyphenylboronic acidHCID 668417974-(4-Methoxy-phenyl)-1H-indole-2-carboxylic acid piperidin-4-ylamide

Product 1

HCID 668417124-(4-Ethoxy-phenyl)-1h-indole-2-carboxylic acid piperidin-4-ylamide

Procedure

This compound has been synthesized from 4-ethoxy-phenyl-boronic acid analogously to the method described in the synthesis of 178 (see example 141).

Sources & evidence

ORD record
ord-e0bef7f2b3d24c23bedbe2b5e6be2184
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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