HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-p-tolyloxy-1H-indole-2-carboxylic acid piperidin-4-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-p-tolyloxy-1H-indole-2-carboxylic acid (1-benzyl-piperidin-4-yl)-amide | HCID 86613489 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-p-tolyloxy-1H-indole-2-carboxylic acid piperidin-4-ylamide | HCID 66841625 | — |
Reaction Steps
Pd—C (1 g) is placed into a flask filled with argon and covered with methanol. 186 (1.4 g, 3.2 mmol) is dissolved in 100 ml of methanol and 1.6 ml of 2M HCl and added. After hydrogenation at room temperature for 5 h the mixture is filtrated over celite and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-b7fb286d6cad414896089cfaf89397a5 |
| Source note | uspto-grants-2010_12 |