Azepan-4-ol → 4-Isobutoxy-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-azepan-1-yl)-ethyl]-piperidin-4-yl}-amide

HRID 2267928Notes

Reaction equation

HRID 2267928 reaction equation
O[CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11]([C:13]2[NH:14][C:15]3[C:20]([CH:21]=2)=[C:19]([O:22][CH2:23][CH:24]([CH3:26])[CH3:25])[CH:18]=[CH:17][CH:16]=3)=[O:12])[CH2:6][CH2:5]1.[NH:27]1[CH2:33][CH2:32][CH2:31][CH:30]([OH:34])[CH2:29][CH2:28]1>>[OH:34][CH:30]1[CH2:31][CH2:32][CH2:33][N:27]([CH2:2][CH2:3][N:4]2[CH2:5][CH2:6][CH:7]([NH:10][C:11]([C:13]3[NH:14][C:15]4[C:20]([CH:21]=3)=[C:19]([O:22][CH2:23][CH:24]([CH3:25])[CH3:26])[CH:18]=[CH:17][CH:16]=4)=[O:12])[CH2:8][CH2:9]2)[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 5149746Azepan-4-olHCID 668416274-Isobutoxy-1H-indole-2-carboxylic acid [1-(2-hydroxy-ethyl)-piperidin-4-yl]-amide

Product 1

HCID 589163224-Isobutoxy-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-azepan-1-yl)-ethyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to example 150 from 4-isobutoxy-1H-indole-2-carboxylic acid [1-(2-hydroxy-ethyl)-piperidin-4-yl]-amide, 190 and azepan-4-ol.

Sources & evidence

ORD record
ord-a361cb40484641bfb83b085d7e7a0fc9
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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