(2H-1,3-benzodioxol-5-yl)boronic acid → 4-Benzo[1,3]dioxol-5-yl-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

HRID 2267936Notes

Reaction equation

HRID 2267936 reaction equation
[N:1]1([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17]([C:19]3[NH:20][C:21]4[C:26]([CH:27]=3)=[C:25](Br)[CH:24]=[CH:23][CH:22]=4)=[O:18])[CH2:12][CH2:11]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:29]1[C:33]2[CH:34]=[CH:35][C:36](B(O)O)=[CH:37][C:32]=2[O:31][CH2:30]1>>[N:1]1([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17]([C:19]3[NH:20][C:21]4[C:26]([CH:27]=3)=[C:25]([C:36]3[CH:35]=[CH:34][C:33]5[O:29][CH2:30][O:31][C:32]=5[CH:37]=3)[CH:24]=[CH:23][CH:22]=4)=[O:18])[CH2:12][CH2:11]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2734371(2H-1,3-benzodioxol-5-yl)boronic acidHCID 596002484-Bromo-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

Product 1

HCID 596002544-Benzo[1,3]dioxol-5-yl-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

Procedure

This compound is synthesized from compound 194 (see example 156) and benzo[1,3]dioxol-5-yl-boronic acid analogously to the method described in Example 156.

Sources & evidence

ORD record
ord-8cab6bf04d154bafa3ab3bd170f6f4af
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

Loading…