4-bromo-1H-indole-2-carboxylic acid → HCID 59600127, compound

HRID 2267939Notes

Reaction equation

HRID 2267939 reaction equation
BrC1C=CC=C2C=1C=C(C(O)=O)N2.[N:14]1([CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][CH:26]([NH:29][C:30]([C:32]3[NH:33][C:34]4[C:39]([CH:40]=3)=[C:38]([Br:41])[CH:37]=[CH:36][CH:35]=4)=[O:31])[CH2:25][CH2:24]2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]C1>>[N:14]1([CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][CH:26]([NH:29][C:30]([C:32]3[NH:33][C:34]4[C:39]([CH:40]=3)=[C:38]([Br:41])[CH:37]=[CH:36][CH:35]=4)=[O:31])[CH2:25][CH2:24]2)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 40426044-bromo-1H-indole-2-carboxylic acidHCID 596002484-Bromo-1H-indole-2-carboxylic acid [1-(2-azepan-1-yl-ethyl)-piperidin-4-yl]-amide

Product 1

HCID 59600127HCID 59600127, compound

Procedure

This compound is synthesized from 4-bromo-1H-indole-2-carboxylic acid and amine 4 analogously to the method described above for the synthesis of 194 (see example 156).

Sources & evidence

ORD record
ord-e7fb7ffceff142ff9618f63d2c78138a
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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