4-bromo-1H-indole-2-carboxylic acid → HCID 59600148, compound

HRID 2267940Notes

Reaction equation

HRID 2267940 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:11]([OH:13])=O)[NH:6]2.Cl.Cl.Cl.[NH2:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][N:26]2[CH2:31][CH2:30][CH:29]([OH:32])[CH2:28][CH2:27]2)[CH2:20][CH2:19]1>>[OH:32][CH:29]1[CH2:28][CH2:27][N:26]([CH2:25][CH2:24][N:21]2[CH2:20][CH2:19][CH:18]([NH:17][C:11]([C:5]3[NH:6][C:7]4[C:3]([CH:4]=3)=[C:2]([Br:1])[CH:10]=[CH:9][CH:8]=4)=[O:13])[CH2:23][CH2:22]2)[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 40426044-bromo-1H-indole-2-carboxylic acidHCID 66841786HCID 66841786, compound

Product 1

HCID 59600148HCID 59600148, compound

Procedure

This compound is synthesized from 4-Bromo-1H-indole-2-carboxylic acid and amine 21 analogously to the method described for 194 (see example 156).

Sources & evidence

ORD record
ord-823eba4cf060497dbfff71ab53725e48
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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