Sodium Hydroxide → HCID 18432358, compound

HRID 2267996Notes

Reaction equation

HRID 2267996 reaction equation
[CH3:1][C:2]1([CH3:17])[C:11]2[C:6](=[C:7]([CH3:16])[C:8]([C:12]([O:14]C)=[O:13])=[CH:9][CH:10]=2)[S:5][CH2:4][CH2:3]1.[OH-].[Na+]>O.CO>[CH3:1][C:2]1([CH3:17])[C:11]2[C:6](=[C:7]([CH3:16])[C:8]([C:12]([OH:14])=[O:13])=[CH:9][CH:10]=2)[S:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11276762HCID 11276762, compound

Product 1

HCID 18432358HCID 18432358, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

62.9 g of methyl 4,4,8-trimethylthiochroman-7-carboxylate were initially charged in 600 ml of a 1:1 mixture of water/methanol, and 15.1 g (0.377 mol) of sodium hydroxide were added. The solution was then heated under reflux for three hours, the organic solvent was removed, 200 ml of water were added and the mixture was made acidic using conc. hydrochloric acid with cooling. The precipitate was filtered off with suction, washed with water and dried.

Workup

  1. additionwere added
  2. temperatureThe solution was then heated
  3. temperatureunder reflux for three hours
  4. customthe organic solvent was removed
  5. addition200 ml of water were added
  6. temperaturewith cooling
  7. filtrationThe precipitate was filtered off with suction
  8. washwashed with water
  9. customdried

Sources & evidence

ORD record
ord-5ab5ed7e0db6402bb7324ee1a8bd7069
Source dataset
uspto-grants-2001_12
Patent number
US06326333B1

Reaction notes

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