Sodium Hydroxide → HCID 18432368, compound

HRID 2268001Notes

Reaction equation

HRID 2268001 reaction equation
[CH3:1][C:2]1[C:7]2[S:8][CH2:9][CH2:10][S:11][C:6]=2[CH:5]=[CH:4][C:3]=1[C:12]([O:14]C)=[O:13].[OH-].[Na+]>O.CO>[CH3:1][C:2]1[C:7]2[S:8][CH2:9][CH2:10][S:11][C:6]=2[CH:5]=[CH:4][C:3]=1[C:12]([OH:14])=[O:13]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18432367HCID 18432367, compound

Product 1

HCID 18432368HCID 18432368, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

9.6 g (0.04 mol) of methyl 8-methyl-2,3-dihydrobenz[1,4]dithiin-7-carboxylate were initially charged in 100 ml of a 1:1 mixture of water/methanol and 2.4 g (0.06 mol) of sodium hydroxide were added. The solution was heated under reflux for two hours, then the organic solvent was distilled off, 200 ml of water were added and the mixture was acidified with cooling using conc. hydrochloric acid. The precipitate was filtered off with suction, washed with water and dried.

Workup

  1. additionwere added
  2. temperatureThe solution was heated
  3. temperatureunder reflux for two hours
  4. distillationthe organic solvent was distilled off
  5. addition200 ml of water were added
  6. temperaturewith cooling
  7. filtrationThe precipitate was filtered off with suction
  8. washwashed with water
  9. customdried

Sources & evidence

ORD record
ord-7c5237285f804d0eaf0cfcd5b48a2260
Source dataset
uspto-grants-2001_12
Patent number
US06326333B1

Reaction notes

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