HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18348362, compound → HCID 18348371, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 18348362 | HCID 18348362 | — |
| Reactant | (3E)-3-Cyclododecen-1-one | HCID 70119724 | — |
| Reactant | HCID 178456138 | HCID 178456138 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18348371 | HCID 18348371 | — |
Reaction Steps
A mixture of mainly E-cyclododec-3-en-1-one (74%) and Z-cyclododec-3-en-1-one (19%) is treated with isopropenylmagnesium bromide in tetrahydrofuran, to form mainly E-1-isopropenylcyclododec-3-en-1-ol. The purified E-1-isopropenylcyclododec-3-en-1-ol is treated with potassium hydride in N,N-dimethylacetamide in the presence of 18-crown-6, that forms a mixture of diastereomeric 2-methyl-4-vinylcyclododecanone and E-2-methylcyclotetradec-5-en-1-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06326349B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-e1dc79443b844bb4b6224dff3ba3cb91 |
| Source note | uspto-grants-2001_12 |