Hydrazine → HCID 18187426, compound

HRID 2268025Notes

Reaction equation

HRID 2268025 reaction equation
C([C:5]1C=CC=[C:7]2[C:8]([NH:10]C(=O)[C:6]=12)=O)CCC.[O:16]=[C:17]1[N:21]([CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[C:20]2[CH:28]=[CH:29][CH:30]=[CH:31][C:19]=2[NH:18]1.NN>CO>[O:16]=[C:17]1[N:21]([CH:22]2[CH2:23][CH2:24][N:25]([CH2:5][CH2:6][CH2:7][CH2:8][NH2:10])[CH2:26][CH2:27]2)[C:20]2[CH:28]=[CH:29][CH:30]=[CH:31][C:19]=2[NH:18]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 70239719HCID 70239719, compound

Product 1

HCID 18187426HCID 18187426, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(2-keto-1-benzimidazolinyl)piperidine butylphthalimide (1.42 g, 3.39 mmol) was dissolved in 30 mL of methanol. To this solution was added anhydrous hydrazine (426 mL, 13.57 mmol) and the reaction mixture was stirred at ambient temperature for 18 hours. The resulting precipitate was filtered and discarded. The filtrate was evaporated to dryness, and the residue was dissolved in dichloromethane and filtered again. The filtrate was evaporated to dryness to give the title compound as a solid.

Workup

  1. filtrationThe resulting precipitate was filtered
  2. customThe filtrate was evaporated to dryness
  3. dissolutionthe residue was dissolved in dichloromethane
  4. filtrationfiltered again
  5. customThe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-3fe0cee671e444f69be83357350796ad
Source dataset
uspto-grants-2001_12
Patent number
US06326372B1

Reaction notes

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