Malonic Acid → 3-Amino-3-(3,4-difluorophenyl)propanoic acid

Participants

Reaction Steps

3,4-Difluorobenzaldehyde (7.76 mL, 70.3 mmol), malonic acid (7.28 g, 70.3 mmol), and ammonium acetate (10.79 g, 140 mmol) were combined in absolute ethanol (30 mL) and refluxed under nitrogen for 6 hours. The mixture was cooled and stirred at ambient temperature overnight. A white solid precipitated which was collected by filtration to yield the title compound.

Provenance & Evidence