HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → N2,N4-bis(4-carboxy-3-methoxyphenyl)-5-fluoro-2,4-pyrimidinediamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N2,N4-bis(3-carboxyphenyl)-5-fluoro-2,4-pyrimidinediamine | HCID 10126258 | — |
| Reactant | N2,N4-bis(3-methoxy-4-methoxycarbonylphenyl)-5-fluoro-2,4-pyrimidinediamine | HCID 22060643 | — |
| Product | N2,N4-bis(4-carboxy-3-methoxyphenyl)-5-fluoro-2,4-pyrimidinediamine | HCID 22060868 | 70% |
Reaction Steps
In a manner analogous to the preparation of N2,N4-bis(3-carboxyphenyl)-5-fluoro-2,4-pyrimidinediamine, N2,N4-bis(3-methoxy-4-methoxycarbonylphenyl)-5-fluoro-2,4-pyrimidinediamine (30 mg, 0.06 mmol) and NaOH (200 mg, 5 mmol) gave N2,N4-bis(4-carboxy-3-methoxyphenyl)-5-fluoro-2,4-pyrimidinediamine (18 mg, 64%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557210B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-cae13727090044dbb85ddecc96e76f89 |
| Source note | uspto-grants-2009_07 |