Styrene → HCID 18348271, compound

Participants

Reaction Steps

A mixture of 9.2 g of 2,6-difluoro-4-[2-(p-ethoxyphenyl)ethyl]phenylboric acid (prepared by reacting 3,5-difluorobenzaldehyde with p-ethoxybenzyltriphenylphosphonium iodide by the Wittig method and subsequently hydrogenating the resulting styrene derivative on Pd/C), 6.0 g of 1-bromo-4-n-propylbenzene, 38 ml of 2 ml [sic] aqueous Na2CO3 solution, 0.6 g of tetrakis(triphenyl-phosphine)palladium(0) an d 75 ml of toluene is refluxed for two hours. The aqueous phase is extracted twice with toluene and combined with the organic phase. Conventional aqueous work-up and chromatographic purification of the residue give 4-[2-(p-ethoxyphenyl)ethyl]-2,6-difluoro-4′-n-propylbiphenyl.

Provenance & Evidence