HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → 5-(9H-fluoren-9-ylmethoxy)-3H-1,3,4-oxadiazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 9-Fluorenylmethyl carbazate | HCID 161883 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | 5-(9H-fluoren-9-ylmethoxy)-3H-1,3,4-oxadiazol-2-one | HCID 10755176 | — |
Reaction Steps
Two equivalents of phosgene (1.89 M in toluene; 4.2 ml) are added to a solution of 995 mg of 9H-fluoren-9-yl-methyl hydrazinecarboxylate in 40 ml of dichloromethane and 40 ml of saturated aqueous NaHCO3 solution. The mixture is stirred for 15 minutes and then worked up as usual, giving 5-(9H-fluoren-9-ylmethoxy)-3H-[1,3,4]oxadiazol-2-one (“A”).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06326403B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-3b3719b6b2cb4825a204e06f2231c490 |
| Source note | uspto-grants-2001_12 |