HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium diisopropylamide → HCID 10089931, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | Tert-butyl 4-(iodomethyl)piperidine-1-carboxylate | HCID 10448961 | — |
| Reactant | 6-Methoxy-3-methyl-1,2-benzoxazole | HCID 12624673 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 10089931 | HCID 10089931 | 80.7% |
Reaction Steps
The procedure described in Example 1d was followed using 6-methoxy-3-methyl-1,2-benzisoxazole (0.32 g, 1.96 mmol), 4-iodomethyl-1-piperidinecarboxylic acid, 1-(1,1-dimethylethyl) ester (0.70 g, 2.15 mmol), and 1M LDA (2.0 mL, 2.0 mmol) in dry THF (3 mL). After purification, the title compound (0.57 g, 80%) was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06326382B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-529e73e23e564e3586967777b7b8c6ee |
| Source note | uspto-grants-2001_12 |