HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-(2-(1-benzylpiperidin-4-yl)ethyl)benzo[d]isoxazol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(1-Benzylpiperidin-4-yl)ethan-1-amine | HCID 1867002 | — |
| Reactant | 3-Chloro-1,2-benzoxazole | HCID 2779780 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-(2-(1-benzylpiperidin-4-yl)ethyl)benzo[d]isoxazol-3-amine | HCID 10449628 | 15.5% |
Reaction Steps
The procedure described in Example 21 was followed with 3-chloro-1,2-benzisoxazole (0.682 g, 4.44 mmol), 4-aminoethyl-1-phenylmethyl piperidine (0.970 g, 4.44 mmol), and K2CO3 (0.614 g, 4.44 mmol) in DMSO (30 mL). After purification, the title compound (0.231 g, 15%) was obtained as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06326382B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-3ee5e4af04cc4e358b7ab5e185871f0b |
| Source note | uspto-grants-2001_12 |