Tetrahydrofuran → HCID 70214617, compound

Participants

Reaction Steps

3.1 g (8.5 mmol) of 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)acryloyloxy]benzaldehyde and 50 ml of a mixture of THF and methanol (50/50) are introduced into a round-bottomed flask. 163 mg (4.25 mmol) of sodium borohydride is added portionwise and the mixture is stirred at [lacuna] temperature for three hours. The reaction medium is poured into water and extracted with ethyl ether, and the organic phase is separated out after settling has taken place, dried over magnesium sulphate, filtered and evaporated. The solid obtained is recrystallized from a mixture of diisopropyl ether and hexane. After filtration and drying, 1.6 g (53%) of 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)acryloyloxy]benzenemethanol, with a melting point of 140-50° C., are collected.

Provenance & Evidence