Hydrochloric Acid → HCID 70215201, compound

Participants

Reaction Steps

2.9 g (7.4 mmol) of methyl 3-{3-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenecarbonyl)-amino]phenyl}acrylate obtained in Example 18, 50 ml of THF and 3.1 g (74 mmol) of lithium hydroxide are introduced into a round-bottomed flask. The reaction medium is refluxed for 24 h ours and then poured into water, acidified to pH 1 with concentrated hydrochloric acid and extracted with ethyl acetate, and the organic phase is separated out after settling has taken place, washed with water, dried over magnesium sulphate and evaporated. The residue obtained is triturated from heptane, filtered off and dried. 2.8 g (100%) of 3-{3-[(5,5,8,8- tetramethyl-5,6,7,8-tetrahydro-2-naphthalenecarbonyl) amino]phenyl}acrylic acid, with a melting point of 215-6° C., are collected.

Provenance & Evidence