Benzenesulfonyl chloride → HCID 18349719, compound

HRID 2268235Notes

Reaction equation

[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:23][CH2:24][CH2:25][CH2:26][N:27]2[CH:31]=[CH:30][N:29]=[CH:28]2)([CH3:22])[CH3:21])=[CH:16][CH:15]=1>ClCCl>[N:27]1([CH2:26][CH2:25][CH2:24][NH:23][C:20]([C:17]2[CH:18]=[CH:19][C:14]([CH2:13][CH2:12][NH:11][S:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)(=[O:9])=[O:8])=[CH:15][CH:16]=2)([CH3:22])[CH3:21])[CH:31]=[CH:30][N:29]=[CH:28]1

Participants

Conditions

Temperature: 0 °C

Procedure

A solution of benzenesulphonyl chloride (0.25 g) in dichloromethane (3 ml) was added dropwise to a solution of N-{1-[4-(2-aminoethyl)phenyl]-1-methylethyl}-3-(imidazol-1-yl)propylamine (0.4 g) in dichloromethane (7 ml) with stirring at 0° C. The mixture was treated in a similar manner to Example 55 to give N-[2-(4-{1-[3-(imidazol-1-yl)propylamino]-1-methylethyl}phenyl)ethyl]benzenesulphonamide as an oil.

Workup

additionThe mixture was treated in a similar manner to Example 55

Sources & evidence

ORD record: ord-a79b1148d4ab4bb3b6ddc682a7c5a0d3
Source dataset: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06326500B1

Reaction notes

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