1H-Imidazole-1-propanal → 1H-Imidazole-1-propanamine

HRID 2268277Notes

Reaction equation

HRID 2268277 reaction equation
C(OC1C=CC(C2C=CC(C([NH2:24])(C)C)=CC=2)=CC=1)C1C=CC=CC=1.[N:25]1([CH2:30][CH2:31][CH:32]=O)[CH:29]=[CH:28][N:27]=[CH:26]1>>[N:25]1([CH2:30][CH2:31][CH2:32][NH2:24])[CH:29]=[CH:28][N:27]=[CH:26]1

Participants

3

Reactant 2

HCID 47122741H-Imidazole-1-propanalHCID 183496501-(4'-Benzyloxybiphenyl-4-yl)-1-methylethylamine

Product 1

HCID 787361H-Imidazole-1-propanamine

Procedure

In a similar manner to Example 24, 1-(4′-benzyloxybiphenyl-4-yl)-1-methylethylamine (A15) (1.4 g) and 3-(imidazol-1-yl)propionaldehyde (0.72 g) were reacted to give N-1-(4′-benzyloxybiphenyl-4-yl)-1-methylethyl)-3-(imidazol-1-yl)propylamine, m.p. 93-95° C.

Sources & evidence

ORD record
ord-fcfe41a0044d4ec0964846d98de2d469
Source dataset
uspto-grants-2001_12
Patent number
US06326500B1

Reaction notes

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