Cyclohexanecarboxaldehyde → (2R,3R,4S,5R)-2-[2-{[(Cyclohexylmethyl)amino]methyl}-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl]-5-(methoxymethyl)tetrahydro-3,4-furandiol

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Reaction Steps

The title compound was prepared by a similar method to example 5 from (2R,3R,4S,5R)-2-{2-(aminomethyl)-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol (example 1) (110 mg, 0.22 mmol), cyclohexanecarboxaldehyde (22 mg, 0.20 mmol) and sodium tnacetoxyborohydnde (70 mg, 0.33 mmol) to afford the title compound as a solid (55 mg). MS: 587 (MH+).

Provenance & Evidence