Benzenesulfonyl chloride → N-(2-{9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(methoxymethyl)tetrahydro-2-furanyl]-6-[(2,2-diphenylethyl)amino]-9H-purin-2-yl}ethyl)benzenesulfonamide

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Reaction Steps

The title compound was prepared by a similar method to example 3 using (2R,3R,4S,5R)-2-{2-(2-aminoethyl)-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol (example 11) (200 mg, 0.40 mmol), benzenesulphonyl chloride (70 mg, 0.40 mmol) and triethylamine (0.15 ml, 1.08 mmol) to afford the title compound as a solid (145 mg). MS: 645 (MH+).

Provenance & Evidence