Acetic Acid → (2R,3R,4S,5R)-2-{6-[(2,2-diphenylethyl)amino]-2-[2-(isopropylamino)ethyl]-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol

Participants

Reaction Steps

The title compound was prepared by a similar method to example 12 using (2R,3R,4S,5R)-2-{2-(2-aminoethyl)-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol (example 11) (120 mg, 0.24 mmol), acetone (14 mg, 0.24 mmol), acetic acid (16 mg, 0.27 mmol) and sodium triacetoxyborohydride (75 mg, 0.35 mmol) to afford the title compound as a solid (55 mg). MS: 547 (MH+).

Provenance & Evidence