Triethylamine → HCID 59975285, compound

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	(2R,3R,4S,5R)-2-{2-(Aminomethyl)-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol	HCID 9897827	—
Reactant	4-(1-(2,2,2-Trifluoroacetyl)piperidin-4-yl)benzene-1-sulfonyl chloride	HCID 17973478	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	HCID 59975285	HCID 59975285	77.2%

Reaction Steps

The title compound was prepared by a similar method to example 3 using (2R,3R,4S,5R)-2-{2-(aminomethy)-6-[(2,2-diphenylethyl)amino}-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol (example 1) (250 mg, 0.51 mmol), 4-[1-(2,2,2-trifluoroacetyl)-4-pipendinyl]benzenesulfonyl chloride (preparation 20) (157 mg, 0.48 mmol) and triethylamine (155 mg, 1.53 mmol) in tetrahydrofuran (25 ml). This gave the title compound as a solid (300 mg). MS: 811 (MH+)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06326359B1
Source dataset	uspto-grants-2001_12
ORD ID	ord-c803b757cd2d47e49ea8fc1515be32ce
Source note	uspto-grants-2001_12