Triethylamine → HCID 59975281, compound

Participants

Reaction Steps

The title compound was prepared by a similar method to example 3 using (2R,3R,4S,5R)-2-{2-(aminomethyl)-6-[(2,2-diphenylethyl)amino}-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol (example 1) (250 mg, 0.49 mmol), 2-methoxy-1-ethanesulfonyl chloride (J. Org. Chem. 2633, 26, 1961) (77 mg, 0.49 mmol), triethylamine (150 mg, 1.5 mmol) in tetrahydrofuran (23 ml). The crude product was purified by column chromatography on silica gel eluting with a solvent system of dichloromethane:methanol:ammonia (96:4:0.2) gave the title compound (225 mg) as an oil. MS: 614 (MH+).

Provenance & Evidence