2-Methoxybenzaldehyde → HCID 69534155, compound

Participants

Reaction Steps

The title compound was prepared by a similar method to example 5 using (2R,3R,4S,5R)-2-{2-(aminomethyl)-6-[(2,2-diphenylethyl)amino}-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol (example 1) (200 mg, 0.4 mmol), sodium triacetoxyborohydnde (152 mg, 0.72 mmol) and 2-methoxybenzaldehyde (75 mg, 0.53 mmol). The product was purified by column chromatography on silica gel eluting with a solvent system of dichloromethane:methanol:ammonia (95:5:0.5), which gave the title compound (53 mg) as a foam. MS: 611 (MH+).

Provenance & Evidence